Erythromelalgia: An Underrecognized Manifestation of Small-Fiber Neuropathy

Erythromelalgia: an underrecognized manifestation of small-fiber neuropathy.

Erythromelalgia is characterized by intermittent heat, redness, and pain affecting the extremities.1 Exercise and increase in temperature are precipitating factors. During symptoms, blood flow and temperature increase without a concomitant increase in oxygenation.2 Severe sudomotor impairment and evidence of peripheral adrenergic dysfunction are also present.2 A recent study showed that a predo...

Erythromelalgia: a cutaneous manifestation of neuropathy?*

The low prevalence of erythromelalgia, classified as an orphan disease, poses diagnostic and therapeutic difficulties. The aim of this review is to be an update of the specialized bibliography. Erythromelalgia is an infrequent episodic acrosyndrome affecting mainly both lower limbs symmetrically with the classic triad of erythema, warmth and burning pain. Primary erythromelalgia is an autosomal...

Chapter 7 Small fiber neuropathy in sarcoidosis

Sjögren Syndrome-Associated Small Fiber Neuropathy

We conducted the current study to analyze the clinical, immunologic, and neurophysiologic features of primary Sjögren syndrome (pSS)-associated sensory small fiber neuropathies (SFNs). Forty consecutive pSS patients with SFN were included. SFN was defined by the presence of suggestive sensory painful symptoms with normal nerve conduction studies and abnormal neurophysiologic tests for small ner...

Small fiber neuropathy: A burning problem.

Small fiber neuropathy is increasingly being recognized as a major cause of painful burning sensations in the feet, especially in the elderly. Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. Diabetes mellitus is the most common identifiable cause of small fiber neuropathy, and impaired oral glucose tolerance and individual...